Which sign might a patient with hypoglycemia exhibit?

A patient experiencing hypoglycemia may exhibit fatigue and irritability as symptoms. This occurs because hypoglycemia, which is characterized by low blood glucose levels, affects the brain and body's ability to function effectively. The brain relies heavily on glucose for energy, and when levels drop, it can lead to a range of neuroglycopenic symptoms, including fatigue, weakness, confusion, and irritability.

Moreover, these symptoms reflect the body's fight-or-flight response to low glucose levels, as the release of adrenaline can contribute to feelings of nervousness or irritability. Symptoms related to hypoglycemia develop as the body attempts to signal that it needs a source of energy, resulting in emotional and physical distress.

The other options do not align with the common presentations of hypoglycemia. High fever typically indicates an infection or inflammatory response, puffiness in the face does not directly relate to glucose levels, and while drowsiness can be a symptom, it is less specific and typically occurs at more severe levels of hypoglycemia compared to fatigue and irritability.